Resumen de Effects of raloxifene and estradiol on bone turnover parameters in intact and ovariectomized rats

S. Canpolat, N. Tug, A. D. Seyran, S. Kumru, b. Yilmaz

• This study was designed to investigate effects of raloxifene (RLX) and estradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups:

  Controls subcutaneously received saline alone. RLX (2 mg/kg) and estradiol (30 ìg/kg) were injected to two groups of animals for a period of 6 weeks at two daily intervals. In the second model, rats (n=24) were ovx and allowed to recover for a period of at least 3 weeks.

  Control group received vehicle alone. Remaining rats were divided into two groups and injected with RLX (2 mg/kg) and estradiol (30 ìg/kg) for 6 weeks. Urine samples were collected from all animals 24 h after the This study was designed to investigate effects of raloxifene (RLX) and estradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups:

  Controls subcutaneously received saline alone. RLX (2 mg/kg) and estradiol (30 ìg/kg) were injected to two groups of animals for a period of 6 weeks at two daily intervals. In the second model, rats (n=24) were ovx and allowed to recover for a period of at least 3 weeks.

  Control group received vehicle alone. Remaining rats were divided into two groups and injected with RLX (2 mg/kg) and estradiol (30 ìg/kg) for 6 weeks. Urine samples were collected from all animals 24 h after the