Impact of radiotherapy delay on survival in glioblastoma

• Autores: Izaskun Valduvieco Ruiz, Eugènia Verger, Lluis Caral, T. Pujol, Teresa Ribalta Farrés, Teresa Boget Llucià, Laura Oleaga, Francesc Graus Ribas
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 15, Nº. 4, 2013, págs. 278-282
• Idioma: inglés
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• Resumen

  • Background Previous studies in glioblastoma have concluded that there is no decrease in survival with increasing time to initiation of RT up to 6 weeks after surgery. Unfortunately, the number of glioblastoma patients who start RT beyond 6 weeks is not small in some countries. The aim of our study was to evaluate the effect of RT delay beyond 6 weeks on survival of patients who have undergone completed resection of a glioblastoma.

    Methods We reviewed 107 consecutive glioblastoma patients who had a complete surgical resection at our hospital. Clinical data, including delay in initiation of RT, were prospectively collected. The impact of single parameters on overall survival was determined by univariate and multivariate analyses.

    Results According to univariate analysis, variables that had a prognostic influence on survival were age (p = 0.036), KPS (p = 0.031), additional treatment with CHT (p < 0.0001), and initiation of RT before 42 days (p = 0.009). Multivariate analysis indicated that Karnofsky performance scale, additional treatment with chemotherapy, and initiation of RT before 6 weeks after surgery were favorable, independent prognostic factors of survival.

    Conclusions Survival is significantly reduced in glioblastoma patients if RT is not initiated within the 6 weeks after complete resection of the tumor.