Study of nephrotic syndrome in children: Importance of light, immunoflourescence and electron microscopic observations to a correct classification of glomerulopathies
- Autores: Muhammed Mubarak, Javed Kazi
- Localización: Nefrología: publicación oficial de la Sociedad Española de Nefrología, ISSN 0211-6995, Vol. 33, Nº. 2, 2013, págs. 237-242
- Idioma: inglés
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Resumen
To evaluate the contribution of electron micros- copy (EM) to the accurate diagnosis of glomerulopathies in childhood nephrotic syndrome (NS) in a developing country.
Methods:
The study was carried out at the Histo- pathology Department, Sindh Institute of Urology and Transplantation (SIUT) from April 2007 to March 2008. All children ( ? 18 years) presenting with NS were included. Pa- tients� demographic, clinical, laboratory, and biopsy data were retrieved from case records and biopsy reports. Re- nal biopsies were studied by light microscopy, immuno- flourescence, and EM.
Results:
The mean age of 74 chil- dren was 11.34±4.85 years. EM was useful in 97.2% of cases, being essential in 31% and helpful in 66.2% cases .
Conclusion:
The results demonstrate that the ultrastructu- ral study is both helpful and essential to a correct classifi- cation of glomerular diseases underlying NS in children in nearly all cases and whenever feasible this should be used in the pathologic evaluation of renal biopsies.
