Genome-Wide Association Studies, Alzheimer Disease, and Understudied Populations

• Autores: Robert L. Nussbaum
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 309, Nº. 14, 2013, págs. 1527-1528
• Idioma: inglés
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• Resumen

  • Genetics researchers have been grappling for decades with the problem of how to identify the genetic variants contributing to disease traits with complex inheritance. In common diseases such as type 2 diabetes, cardiovascular disease, and late-onset Alzheimer disease (LOAD), a contribution by genetic variants can be inferred because these diseases are �familial�; ie, the more genetically related a relative is to the affected person, the more frequently the relative is also affected.