Circulating Dopamine and C-Peptide Levels in Fasting Nondiabetic Hypertensive Patients:: The Graz Endocrine Causes of Hypertension study

• Autores: Andreas Tomaschitz, Eberhard Ritz, Katharina Kienreich, Burkert Pleske, Winfried März, Bernhard O. Boehm, Christiane Drechsler, Andreas Meinitzer, Stefan Pilz
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 8, 2012, págs. 1771-1773
• Idioma: inglés
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• Resumen

  • Accumulating evidence supports a potential role for dopamine in the regulation of insulin secretion. We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension (GECOH) study. After 12 h of fasting, we measured plasma dopamine and serum C-peptide levels and established determining factors of insulin secretion in 201 nondiabetic hypertensive patients (mean age 48.1 ± 16.0 years; 61.7% women). Mean dopamine and C-peptide concentration were 33.4 ± 38.6 pg/mL and 3.1 ± 2.7 ng/mL, respectively. A strong and inverse correlation was observed between dopamine and C-peptide levels (r = -0.423, P < 0.001). There was no significant relationship between C-peptide, plasma epinephrine, and norepinephrine. C-peptide levels decreased steadily and significantly from tertile 1 of dopamine (3.6 ng/mL [95% CI 2.9-4.1]) to tertile 3 (1.6 ng/mL [1.5-2.7], P < 0.001) after multivariate adjustment. The inverse association between dopamine and C-peptide highlights the need to evaluate whether dopamine could be effective for modulating endocrine pancreatic function.