Vista Cutaneous Structural and Biochemical Correlates of Foot Complications in High-Risk Diabete

• Autores: Abd A. Tahrani, Wei Zeng, Jayadave Shakher, Milan K. Piya, Sharon Hughes, Kiran Dubb, Martin J. Stevens
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 9, 2012, págs. 1913-1918
• Idioma: inglés
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• Resumen

  • [...]we sought to compare skin biochemical and structural deficits in subjects with and without specific diabetic foot complications. Nonetheless, such a linear relationship does exist in our cohort, and previous reports indicate a linear reduction in skin thickness and elasticity with age (24,25). [...]the subjects with DPN alone and those with foot complications were of similar age and, thus, this factor could not account for the differences observed. [...]increased PARP, reduced type 1 procollagen, and impaired skin structure are associated with the development of foot complications in diabetes and may constitute novel biomarkers to identify patients at maximal risk.