Cutaneous Features of Crouzon Syndrome With Acanthosis Nigricans

• Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 149, Nº. 6, 2013, págs. 737-741
• Idioma: inglés
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• Resumen

  • Importance Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described.

    Observations We report 6 cases and summarize the existing literature with regard to the cutaneous manifestations of this disorder. All patients have widespread, early-onset acanthosis nigricans. Patients often have prominent hypopigmented scars at surgical sites and nevi arising early in childhood.