What Is the Relevance of Antimicrobial Resistance on the Outcome of Community-Acquired Pneumonia Caused by Streptococcus pneumoniae? (Should Macrolide Monotherapy Be Used for Mild Pneumonia?)

• Autores: Donald E. Low
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 27, Nº. 1, 2013 (Ejemplar dedicado a: Community-Acquired pneumonia: Controversies and questions), págs. 87-97
• Idioma: inglés
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• Resumen

  • Multidrug-resistant pneumococci continue to increase worldwide. Although there are still questions regarding the relevance of ?-lactam resistance, the recommendation for the use of the macrolides as monotherapy for mild community-acquired pneumonia should be revisited in view of high rates of resistance, the association of clinical failures with low-level and high-level resistance, and the lack of clinical data to support their need for empirical therapy for the atypicals.