IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated With a General Celiac-Specific Lower Immune Response in Comparison With Nondiabetic Celiac Patients at Diagnosis

• Autores: Claudio Tiberti, Francesca Panimolle, Margherita Bonamico, Blegina Shashaj, Tiziana Filardi, Federica Lucantoni, Raffaella Nenna, Francesco Costantino, Andrea Lenzi, Susanna Morano
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 10, 2012, págs. 2083-2085
• Idioma: inglés
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• Resumen

  • To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac -specific humoral immunoreactivity occurs similarly to that in nondiabetic patients at celiac disease (CD) diagnosis. IgA anti-transglutaminase autoantibody (IgA-tTGAb) was detected in 654 new-onset DM1 sera. IgA-tTGAb^sup +^ DM1 sera were subsequently analyzed for IgG-tTG, deamidated gliadin (DGP), and actin antibodies, and results were compared with those found in 83 screen-detected nondiabetic patients at CD diagnosis. A total of 12.8% DM1 sera were IgA-tTGAb^sup +^, with a lower autoantibody frequency in adult patients aged >18 years (6.8 vs. 15.1%, aged ?18 years; P = 0.005). IgA-tTGAb titers, IgG-tTGAb, and DGPAb frequency/titers and mean number of celiac-autoantibody positivities per patient were significantly lower in IgA-tTGAb^sup +^ DM1 compared with nondiabetic CD patients. Age of diabetes onset is negatively associated with risk of CD. The celiac-specific humoral immunoreactivity at DM1 onset is significantly lower compared with that found in nondiabetic patients at CD diagnosis.