Helicobacter pylori in Gastric Carcinogenesis: Mechanisms

• Autores: Lydia E. Wroblewski, Richard M. Peek
• Localización: Gastroenterology clinics of North America, ISSN 0889-8553, Vol. 42, Nº. 2, 2013 (Ejemplar dedicado a: Gastric Cancer), págs. 285-298
• Idioma: inglés
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• Resumen

  • Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pyloriinfection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.