A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes

• Autores: Jessica Chang, Antonietta Russo, Michelle Bound, Christopher K. Rayner, Karen L. Jones
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 12, 2012, págs. 2594-2596
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • To evaluate the natural history of gastric emptying in diabetes. Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years. [PUBLICATION ABSTRACT]