Resumen de Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: a meta-analytic study

Rafael Lima Verde Osterne, Phelype Maia Araújo, Abrahao Cavalcante Gomes de Souza-Carvalho, Roberta Barroso Cavalcante, Eduardo Sant'ana, Renato Luiz Maia Nongueira

• Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intral - esional corticosteroid injections.

  Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and develop - ment of a descriptive meta-analysis of the results.

  Results: Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Consider - ing the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections.

  Conclusion: In view of the results analyzed, intralesional corticosteroid injections could be considered as first treat - ment option for central giant cell lesion.