Isolation of T-lymphotropic retrovirus from a patient at risk for acquired immune defficiency syndrome (AIDS)

• Autores: F Barré-Sinoussi, J. C Chermann, F Rey, M. T Nugeyre, S Chamaret, J Gruest, C Dauguet
• Localización: Revista de investigación clínica, ISSN 0034-8376, ISSN-e 2564-8896, Vol. 56, Nº. 2 (MAR-ABR), 2004, págs. 126-129
• Idioma: español
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• Resumen

  • A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTVL), but claearly distinct from each previous isolate has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired imune deficiency syndrome (AIDS). This virus is a thypical type-C RNA tumor virus, buds from the cell membrace, prefers magnesium for reseve transcriptase activity, an has an internal antigen (p25) similar to HTVL p24. Antibodies from serum of this patient react with proteins from viruses of the HTVL-1 subgroup, but type-specific antisera to HTVL-1 do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus pruduced by these cell is similar to the original isolate. From these sudies it is conclude that this virus as the previous HTVL isolate belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in human and may be involved in several pathological syndromes, including AIDS