May T1 diabetes mellitus protect from asthma

• Autores: M. Tosca, Michela Silòvestri, Giuseppe D' Annunzio, Renata Lorini, Giovanni Arturo Rossi, G. Ciprandi
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 41, Nº. 5, 2013, págs. 288-291
• Idioma: inglés
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• Resumen

  • Background Type 1 diabetes mellitus (T1DM) may be associated with allergy. It was previously reported that >20% of children with T1DM had allergic rhinitis (AR), but none was asthmatic. This finding was surprising as allergic rhinitis is frequently associated with asthma and asthma prevalence is about 10% of the general paediatric population. Thus, it was hypothesized that T1DM could protect from asthma.

    Objectives The aim of this preliminary study was to evaluate the pulmonary function and the response to bronchodilation testing in children, suffering from T1DM with associated AR, comparing them with a control group of children with AR alone.

    Methods Twenty children with T1DM and AR were compared with 59 children with AR alone; spirometry and bronchodilation testing were performed in all patients.

    Results There were no statistically significant differences in both �at baseline� and after bronchodilation testing about FVC, FEV1, and FEF25�75 values. However, changes in �post-bronchodilator� values of FEF25�75 (?FEF25�75) were significantly higher in children with AR alone than in children with T1DM and AR (p = 0.04).

    Conclusions This preliminary study could sustain the hypothesis that T1DM in children suffering also from AR might exert a protective effect of preventing the possible evolution in asthma.