Catching HIV -in the act- with 3D electron microscopy

• Autores: Lesley A. Earl, Jeffrey D. Lifson, Sriram Subramaniam
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 21, Nº. 8, 2013, págs. 397-404
• Idioma: inglés
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• Resumen

  • The development of a safe, effective vaccine to prevent HIV infection is a key step for controlling the disease on a global scale. However, many aspects of HIV biology make vaccine design problematic, including the sequence diversity and structural variability of the surface envelope glycoproteins and the poor accessibility of neutralization-sensitive epitopes on the virus. In this review, we discuss recent progress in understanding HIV in a structural context using emerging tools in 3D electron microscopy, and outline how some of these advances could be important for a better understanding of mechanisms of viral entry and for vaccine design.