Resumen de Angiopoietin-Like Protein 2 and Risk of Type 2 Diabetes in a General Japanese Population: The Hisayama Study

Yasufumi Doi, Toshiharu Ninomiya, Yoichiro Hirakawa, Otowa Takahashi

• Abstract OBJECTIVE To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM).

  RESEARCH DESIGN AND METHODS A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: <2.15, 2.16�2.71, 2.72�3.40, and =3.41 ng/mL. During follow-up, 221 participants developed T2DM.

  RESULTS In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14�2.85; P = 0.01).

  CONCLUSIONS Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels.