Malignant lymphoma of the oral cavity and the maxillofacial region: overall survival prognostic factors

• Autores: Janet Ofelia Guevara Canales, Rafael Morales Vadillo, Sonia Julia Sacsaquispe Contreras, Carlos Barrionuevo Cornejo, Jaime Montes Gil, Carlos Enrique Cava Vergiú, Fernando Augusto Soares, Henrique Duque de Miranda Chaves Netto, Maria das Graças Afonso Miranda Chaves
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 18, Nº. 4, 2013, págs. 619-626
• Idioma: inglés
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• Resumen

  • Objective: To identify the overall survival and prognostic factors of malignant lymphoma of the oral cavity and the maxillofacial region.

    Study Design: Clinical records data were obtained in order to determine overall survival at 2 and 5 years, the individual survival percentage of each possible prognostic factor with the actuarial technique, and the survival regarding the possible prognostic factors with the actuarial technique and the Log-rank and Cox's regression tests.

    Results: Of 151 subjects, an overall survival was 60% at 2 years, and 45% at 5 years. The multivariate analysis demonstrated statistically significant differences for clinical stage (p=0.002), extranodal involvement (p=0.030), presence of human immunodeficiency virus (p=0.032), and presence of Epstein-Barr virus (p=0.010).

    Conclusion: The advanced clinical stage and the larger number of involved extranodular sites are related to a lower overall survival, as well as, the presence of previous infections such as the human immunodeficiency and the Epstein-Barr virus.