Resumen de Carotid Artery Function in Children with Idiopathic Nephrotic Syndrome

Nakysa Hooman, Roya Isa-Tafreshi, Seyed Hassan Mostafavi, Farideh Hallaji, Hasan Otukesh

• Background:

  Nephrotic patients are prone to atheroscle - rosis in consequence of frequent exposures to hyperlipid - emia, hypertension, and immunosuppressive drugs.

  Objec - tives:

  We studied the carotid parameters as early indicators of atherosclerosis in children with nephrotic syndrome.

  Methods:

  Between 2008 and 2011, 51 children with his - tory of nephrotic syndrome enrolled in the study. The in - clusion criteria were: idiopathic nephrotic syndrome with normal serum complement, at least one year after initia - tion of disease, glomerular filtration rate more than 20mL/ min/1.73m 2 , age over two years old at the time of study.

  Seventy-five healthy sex-age-matched children considered as a control group. Carotid function parameters and left ventricular mass index were studied in nephrotic chil - dren.

  Results:

  Steroid sensitive, resistant, and dependent nephrotic syndrome included one-third each. The mean carotid intima-media thickness (mm) in nephrotic children was 0.42 (±.14) while the mean cIMT in controls was 0.37 (±.08) ( P -value <.05). After log transformation, General Linear Multivariate analysis revealed significant difference of carotid intima-media thickness in nephrotic patients ( P - value <.001). Subsequently, the factor that influenced on cIMT was duration of disease ( P <.05). One-half of nephrotic children who had echocardiography, showed left ventric - ular hypertrophy. It was correlated with carotid stiffness and systolic hypertension ( P <.05).

  Conclusions:

  Carotid intima-media thickness was thicker in nephrotic children.

  Carotid parameters were influenced by duration of disease and hypertension.