Resumen de Cholesterol: fa(s)t-food for enterovirus genome replication

Jeroen R. P. Strating, Hilde M. van der Schaar, Frank J.M. van Kuppeveld

• Hijacking and remodeling of host membranes is an obligatory step in the replicative cycle of (+)RNA viruses, including enteroviruses. Ilnytska et al. unveiled in Cell Host & Microbe that enteroviruses usurp clathrin-mediated endocytosis to shuttle cholesterol to sites of genome replication and that cholesterol is needed for efficient replication.