Primary tumor vascularity in esophagus cancer: CD34 and HIF1-? expression correlate with tumor progression

• Autores: Mariusz Ad Goscinski, Jahn Marthin Nesland, Hari Prasad Dhaka
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 28, Nº. 10, 2013, págs. 1361-1368
• Idioma: inglés
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• Resumen

  • Objective: Hypoxia inducible factor ? (HIF1-?) is a key protein regulating the response of a variety of genes and pathways, including angiogenesis, to hypoxic stimuli. High vascularity in various carcinomas correlates with invasion and metastasis. Assessment of primary tumor vascularity and HIF1-? expression in esophageal carcinomas was an objective of this study.

    Methods: The vascularity in esophageal carcinomas (n=52) was quantified by Chalkley method on CD34 immunostained sections. HIF1-? expression was examined by immunohistochemistry. The relationships between CD34 Chalkley count, HIF1-? and various clinico-pathological characteristics with clinical outcome were evaluated.

    Results: High HIF1-? expression in squamous cell carcinoma (SCC) was significantly associated with the T3-4 group (p=0.02). A higher percentage of SCC with high HIF1-? expression compared to its expression in adenocarcinoma (AC) (p=0.005) was observed. In the SCC group, high CD34 Chalkley count and high HIF1-? expression implied a significantly reduced survival (p=0.003 and p=0.001). No such significant association was found in the AC group.

    Conclusions: HIF1-? expression is different in two separate tumor microenvironments: SCCs and ACs of the esophagus. This suggests that different mechanisms may be involved in HIF1-? expression- and activity between the two histological types of esophageal carcinoma.