Resumen de Taking the STING out of cytosolic DNA sensing

Elie J. Diner, Russell E. Vance

• Detection of cytosolic DNA activates a downstream signaling molecule called STimulator of INterferon Genes (STING). Inappropriate or excessive activation of STING can lead to autoimmune disease. A new paper in Cell addresses the important question of how STING-dependent signaling is normally constrained.