Reprogramming antitumor immunity

• Autores: Joseph G. Crompton, David Clever, Raul Vizcardo, Mahendra Rao, Nicholas P. Restifo
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 4, 2014, págs. 178-185
• Idioma: inglés
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• Resumen

  • Regenerative medicine holds great promise in replacing tissues and organs lost to degenerative disease and injury. Application of the principles of cellular reprogramming for the treatment of cancer, however, is not well established. Here, we present an overview of cellular reprogramming techniques used in regenerative medicine, and within this context, envision how the scope of regenerative medicine may be expanded to treat metastatic cancer by revitalizing an exhausted and senescent immune system.