Loop de loop: viral RNA evades IFIT1 targeting

• Autores: Justin A. Roby, Brian D. Clarke, Alexander A. Khromykh
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 4, 2014, págs. 171-173
• Idioma: inglés
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• Resumen

  • In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1.