Late-Life Factors Associated with Healthy Aging in Older Men

• Autores: Christina Bell, Randi Chen, Kamal Masaki, Priscilla Yee, Qimei He, John Grove, Timothy Donlon, J. David Curb, D. Craig Willcox, Leonard W. Poon, Bradley J. Willcox
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 62, Nº. 5, 2014, págs. 880-888
• Idioma: inglés
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• Resumen

  • Objectives: To identify potentially modifiable late-life biological, lifestyle, and sociodemographic factors associated with overall and healthy survival to age 85.

    Design: Prospective longitudinal cohort study with 21 years of follow-up (1991�2012).

    Setting: Hawaii Lifespan Study.

    Participants: American men of Japanese ancestry (mean age 75.7, range 71�82) without baseline major clinical morbidity and functional impairments (N = 1,292).

    Measurements: Overall survival and healthy survival (free from six major chronic diseases and without physical or cognitive impairment) to age 85. Factors were measured at late-life baseline examinations (1991�1993).

    Results: Of 1,292 participants, 1,000 (77%) survived to 85 (34% healthy) and 309 (24%) to 95 (<1% healthy). Late-life factors associated with survival and healthy survival included biological (body mass index, ankle�brachial index, cognitive score, blood pressure, inflammatory markers), lifestyle (smoking, alcohol use, physical activity), and sociodemographic factors (education, marital status). Cumulative late-life baseline risk factor models demonstrated that age-standardized (at 70) probability of survival to 95 ranged from 27% (no factors) to 7% (?5 factors); probability of survival to 100 ranged from 4% (no factors) to 0.1% (?5 factors). Age-standardized (at 70) probability of healthy survival to 90 ranged from 4% (no factors) to 0.01% (?5 factors). There were nine healthy survivors at 95 and one healthy survivor at 100.

    Conclusion: Several potentially modifiable risk factors in men in late life (mean age 75.7) were associated with markedly greater probability of subsequent healthy survival and longevity.