The target cell genus does not matter

• Autores: Sophie Bleves, Thibault G. Sana, Romé Voulhoux
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 6, 2014, págs. 304-306
• Idioma: inglés
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• Resumen

  • Two type VI secreted phospholipases D of Pseudomonas aeruginosa were identified as trans-kingdom virulence effectors, targeting both prokaryotic and eukaryotic host cells. Each of them triggers killing bacterial competitors and internalization into non-phagocytic cells. These type VI lipolytic enzymes are widely distributed among pathogens and may constitute a conserved strategy.