Schwannomas, bening tumors with a senescent phenotype

• Autores: Sara Simonetti, C. Serrano, J. Hernández Losa, Silvia Bagué, R. Orellana Fernández, Claudia M. Valverde, Matilde Esther Lleonart Pajarin, M. Aizpurua Gómez, Joan Carles Galcerán, Santiago Ramón y Cajal Agüeras, Cleofé Romagosa
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 29, Nº. 6, 2014, págs. 721-730
• Idioma: inglés
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• Resumen

  • Background: Schwannomas are benign nerve sheath tumors that only very rarely undergo malignant changes. Oncogenic-induced senescence is a defense mechanism against such malignant transformation. Different molecular pathways are involved in this process, such as RAS-RAF-MAPK. Based on the fact that the RAS-RAF-MAPK pathway is known to be activated in peripheral nerve sheath tumors, this study analyzes senescence markers in Schwannomas to demonstrate the possible role of senescence in their genesis. Methods: A retrospective immunohistochemical study was done in 39 schwannoma and 18 malignant peripheral nerve sheath tumors (MPNST). Staining for p16INK4a, Ki67, p53 and CyclinD1 was performed in all the cases. Additionally, ß-galactosidase staining was done in those cases in which frozen tissue was available (n=8). Results: Higher levels of p16INK4a (p=0.0001) and lower levels of Ki67 (p=0.0001) were found in Schwannomas. Beta-galactosidase activity was positive in 5/5 Schwannomas and negative in 3/3 MPNST. Conclusions: Our results support the senescence nature of Schwannomas and the absence of a senescence phenotype in MPNST.