Resumen de Association of single nucleotide polymorphisms of interleukin-1 family with atopic dermatitis

N. Behniafard, M. Gharagozlou, S. Sotoudeh, E. Farhadi, M. Khaledi

• Background Interleukin-1 (IL-1) seems to have an important role in early reactions towards microbes, while its genetic variability could affect this role in atopic patients who have a distressed immunity towards dermatological infections.

  Methods Eighty-nine patients with atopic dermatitis (AD), who were referred to a main referral paediatric hospital, were enrolled in this study. Single nucleotide polymorphisms (SNP) of the following IL-1 cluster genes were assessed in this group of patients: IL-1? -889, IL-1? -511, IL-1? +3962, IL-1R Pst-I 1970, and IL-1RA Mspa-I 11100. The results were compared with a group of 140 healthy subjects from the same region.

  Results Fourteen percent of the controls had TT homozygous genotype in IL-1R at position Pst-I 1970, while only 2% of the patients with AD had this genotype (p = 0.005, OR: 0.14, 95%CI: 0.02�0.64). The CC homozygous genotype was the most common genotype in IL-1? position -889 and IL-1? at position +3962 in both groups of patients with AD and the controls, while the TC heterozygous genotype was the most common genotype in IL-1? at position -511 and IL-1R at position Pst-I 1970, with no significant difference between the two groups.

  Conclusions This study showed a significant negative association in the IL-1R Mspa-I 11100 TT homozygous genotype in the patients with AD.