Osteonecrosis de mandíbula asociada a bifosfonatos intravenosos en un paciente con mieloma múltiple

• Autores: Cristina Calderón Acedos, María Segura Bedmar, J. Sánchez Guilarte, V. Greciano Greciano, Ángela Flores Juberías
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 7, Nº. 6, 2005, págs. 476-479
• Idioma: español
• Títulos paralelos:
  • Jaw osteonecrosis associated with intravenous biphosphonates in patient with multiple myeloma
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• Resumen

  • Biphosphonates inhibit bone resorption produced by osteoclasts, even though their action mechanism has not been yet completely determined. Intravenous biphosphonates are used with quite frequency in the treatment of bone disease associated with multiple myeloma. Recently, the association of these drugs with the development of jaw osteonecrosis, a complication that may lead to collapse and loss of segments from the maxillary bones, has been reported. We present the case of a 65-year-old male diagnosed with multiple myeloma, who has followed a long-term therapy with intravenous biphosphonates and has developed jaw osteonecrosis after a dental extraction. The injuries are refractory to débridements and periodic antibiotic treatments. Because intravenous biphosphonates have become a standard regimen in the treatment of multiple myeloma, it is critical to be aware of this complication and its clinical significance, since it produces an important negative effect on quality of live of these patients