Monitorización de ciclosporina: Repercusiones clínicas en función de la hora de obtención de la muestra

• Autores: Rafael García Delgado, Alberto Sánchez Romero, Eduardo Escario Travesedo
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 6, Nº. 6, 2004, págs. 398-402
• Idioma: español
• Títulos paralelos:
  • Cyclosporine monitoring: Clinical repercussions based on the collection time of samples
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• Resumen

  • Immunosuppression with cyclosporine (CsA) has improved the levels of transplant survival. Monitoring of its blood levels is still the most useful method for dosage customization. The only procedure that allows for an exact measurement of the exposure to the drug is the determination of the area under the curve from 0 to 12 hours (AUC 0-12). This cannot be accomplished in daily clinical practice. Classically, the procedure used for the dosage adjustment was the determination of the trough level (C 0). Recent studies found a poor correlation between C 0 and AUC 0-12 and recommended the extraction of a blood sample at 2 hours from the intake (C 2) as a parameter that better predicts the degree of exposure to CsA. The objective is to review the existing literature about measurement parameters to improve the efficiency of monitoring the CsA blood levels