Subcutaneous trastuzumab: drug development and current position

• Autores: Paloma Martín Martorell, Begoña Bermejo de las Heras, José Alejandro Pérez Fidalgo, Marisol Huerta Alvaro, Miguel Martín Jiménez, Joan Albanell Mestres, Ana Lluch Hernández
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 16, Nº. 10, 2014, págs. 859-864
• Idioma: inglés
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• Resumen

  • HER2-positive breast cancer, accounting for 15 % of the total breast cancer patient population, carries in itself a bad prognosis, which has now become much better after the advent of anti-HER2 drugs. HER2-targeted therapy has significantly improved disease free- and overall survival in HER2-positive breast cancer, and has rendered better disease control both in the early and advanced disease setting. Trastuzumab treatment duration is often prolonged and poses significant time and resource challenges both on the treatment institutions and on the patient. The recent development of a subcutaneous formulation has meant a significant advance in this respect. We review the drug development of the compound and the current evidence on its use.