PIP2: choreographer of actin-adaptor proteins in the HIV-1 dance

• Autores: Vera Rocha Perugini, Mónica Gordon Alonso, Francisco Sánchez Madrid
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 7, 2014, págs. 379-388
• Idioma: inglés
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• Resumen

  • The actin cytoskeleton plays a key role during the replication cycle of human immunodeficiency virus-1 (HIV-1). HIV-1 infection is affected by cellular proteins that influence the clustering of viral receptors or the subcortical actin cytoskeleton. Several of these actin-adaptor proteins are controlled by the second messenger phosphatidylinositol 4,5-biphosphate (PIP2), an important regulator of actin organization. PIP2 production is induced by HIV-1 attachment and facilitates viral infection. However, the importance of PIP2 in regulating cytoskeletal proteins and thus HIV-1 infection has been overlooked. This review examines recent reports describing the roles played by actin-adaptor proteins during HIV-1 infection of CD4+ T cells, highlighting the influence of the signaling lipid PIP2 in this process.