Hipersensibilidad a oxaliplatino. Pruebas cutáneas y protocolo de desensibilización

• Autores: Susana Cortijo Cascajares, M. P. Goyache-Goñi, M.J. Vicario Zubizarreta, Mª Jesús Jiménez Cerezo, G. García Canto
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 6, Nº. 1, 2004, págs. 28-34
• Idioma: español
• Títulos paralelos:
  • Hypersensitiveness to oxaliplatin. Cutaneous tests and desensitization protocol
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• Resumen

  • Objectives: To evaluate the hypersensitiveness reactions to oxaliplatin (L-OHP), a chemotherapeutic agent used as a first-degree treatment for metastatic colorectal cancer; and the need for continuing with the treatment. To standardize the concentrations of L-OHP necessary for the making of cutaneous tests and the establishment of a desensitization protocol. Method: It was developed a study of patients treated with L-OHP that presented symptoms of anaphylaxis during the course of the treatment and it took place a revision of the available information in the literature. Results: The allergologic study was negative and a desensitization regime was successfully developed. Conclusions: The hypersensitiveness reactions to chemotherapeutic agents do not necessarily require the exclusion of such drugs from the treatment regime, because when a desensitization protocol is followed a safe administration of such drugs is achieved