Resumen de Interoperable executive library for the simulation of biomedical processes

Andrew Kail, Kwai Wong, Henian Xia, Xiaopeng Zhao

• We present an Interoperable Executive Library (IEL) built to run, in parallel, a collection of multi-component tasks focusing on simulating complex biomedical phenomena of the heart. The IEL is a light-weight software integrator designed for managing the distribution of data and memory, coordinates communication among parallel processes, and directs execution of a set of loosely coupled numerical and physics tasks or modules.

  The dynamical process of the heart uses computing modules of electrical generation, physiological signal propagation, mechanics deformation, and fluid flow transportation.

  The cardiac electro-physiology is represented by a reaction�diffusion equations using the Beeler�Reuter model. The contracting motion of the heart is described by the continuum mechanical equilibrium equations. At the end of a heart beat, the fluid flow pattern inside the ventricle is computed by solving the incompressible Navier�Stokes equations.

  The finite element method is used to solve these loosely coupled sets of equations.

  Simulations are performed on two simplified heart models as well as a dog ventricle. The functionality and performance of the IEL framework on a distributed computing system are demonstrated and shown.