Dystonia associated to the use of an anti-anorexigenic syrup containing metoclopramide

• Autores: Inmaculada Nacle López, Amparo Moreno Villar, A. Gil Rodríguez, Teresa Ruiz-Rico Ruiz-Morón, A. M. Lara Palma
• Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 16, Nº. 4, 2014, págs. 293-295
• Idioma: inglés
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• Resumen

  • Metoclopramide is a benzamide, which belongs to the class of neuroleptics and it is principally used for its antiemetic and prokinetic properties. We described a case of a three-year-old boy, who presented somnolence, nervousness and muscle twitches 45 minutes after ingesting a dose of Anti-Anorex triple® syrup (is an association of dimethylaminoethanol acetylglutamate, cyproheptadine hydrochloride and metoclopramide hydrochloride), which is indicated for anorexia. After applying the modified Causality Algorithm by Karch and Lasagna, the relationship between dystonia and Anti-Anorex triple® syrup was assigned the category «probable». We consider the need for vigilance in the use of drugs containing metoclopramide in combination with other active ingredients, which are not subject to medical prescription, especially in children who have a higher probability of developing adverse reactions, even with therapeutic doses or with just one shot