Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success

• Autores: Liam S. Redgrave, Sam B. Sutton, Mark A. Webber, Laura J. V. Piddock
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 8, 2014, págs. 438-445
• Idioma: inglés
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• Resumen

  • Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.