Monkey-adapted HIV-1 highlights in vivo significance of restriction factors

• Autores: Andrea Kirmaier, Welkin E. Johnson
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 9, 2014, págs. 486-487
• Idioma: inglés
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• Resumen

  • HIV-1 was isolated 31 years ago, yet models for studying HIV-1 pathogenesis in vivo are still lacking. Recent experiments using an HIV-1 strain engineered to replicate in macaques recapitulate several important features of human AIDS, and provide insight into the genetics of cross-species transmission and emergence of pathogenic retroviruses.