Random yet deterministic: convergent immunoglobulin responses to influenza

• Autores: Andrew J. Martins, John S. Tsang
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 9, 2014, págs. 488-489
• Idioma: inglés
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• Resumen

  • B cell clonal expansion is a hallmark of host-defense and vaccination responses. Given the vast immunoglobulin repertoire, individuals may expand B cells carrying largely distinct immunoglobulin genes following antigenic challenge. Using immunoglobulin-repertoire sequencing to dynamically track responses to influenza vaccination, Jackson et al. find evidence of convergent immunoglobulin responses across individuals.