Artistic creation has always reflected the spirit of the moment, and opera has not been an exception. There are several examples of operas that appeared at key moments of the development of science, portraying them. Additionally, there are also operas that emerged after scientific events or the lifetime of the scientists by whom they were inspired. In what concerns chemistry, the first category could be exemplified by the apothecary operas (already discussed in a previous paper), while the others could be illustrated by recent operas such as Doctor Atomic or Madame Curie. Continuing the endeavor of establishing relations between opera and chemistry, and considering that the history of science plays an important role in the process of teaching and learning sciences, some milestones of the history of chemistry are here revisited through the opera glass. The operas analyzed have been grouped in the following categories: operas of fire and metallurgy, operas of the philosophers of antiquity, operas of alchemy, operas of the Age of Enlightenment, operas of the revolutions, and operas of entropy.
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