GC-MS Analysis of gamma-Hydroxybutyric Acid Analogs.

• Autores: Colin Henck, Luke Nally
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 84, Nº 11, 2007, págs. 1813-1815
• Idioma: inglés
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• Resumen

  • An upper-division forensic chemistry experiment is described. It involves using glycolic acid and sodium glycolate as analogs of ?-hydroxybutyric acid and its sodium salt. The experiment shows the use of silylation in GC�MS analysis and gives students the opportunity to work with a commonly used silylating reagent, N,O-bis[trimethylsilyl]trifluoroacetamide (BSTFA). GC�MS is used to show the problem with analyzing an organic acid without derivatization and to analyze the products of silylation.