MiR-215/192 participates in gastric cancer progression

• Autores: Y. J. Xu, Yun Fan
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 17, Nº. 1, 2015, págs. 34-40
• Idioma: inglés
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• Resumen

  • Introduction Growing evidence indicates that microRNAs (miRNAs) play critical roles in cancer progression. However, the role of miR-215 or miR-192 in gastric carcinogenesis remains unclear at this point.

    Materials and methods Quantitative real-time PCR analysis is used to detect the expression levels of miR-215 or -192. Matrigel invasion assay is used to explore the effects of miR-215 or -192 on gastric cancer cells invasion ability. Statistical analysis is carried out by SPSS 19.0 software.

    Results MiR-215/192 is significantly up-regulated in gastric cancer tissues from gastrectomy. The up-regulation of miR-215 or -192 was related with the clinical characteristics of gastric cancer, such as lymph node metastasis. Inhibition of miR-215/192 significantly suppressed gastric cancer cell invasion. Statistical analysis indicated that the expression of miR-215 or -192 may be a potential candidate biomarker for gastric cancer prognosis.

    Conclusions These data suggest that frequently up-regulated miR-215/192 in gastric cancer may participate in gastric cancer progression.