Correlates of Periodontal Decline and Biologic Markers in Older Adults

• Autores: Jessica R. Swoboda, H. Asuman Kiyak, Richard Darveau, G. Rutger Persson
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 79, Nº. 10, 2008, págs. 1920-1926
• Idioma: inglés
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• Resumen

  • Background: There is limited information on infectious and host responses distinguishing older people with or without active periodontitis. This study measured bacterial and serum cytokine and high-sensitivity C-reactive protein (hsCRP) levels in older persons.

    Methods: Elders (mean age: 67 years), whose periodontal status had declined most or least (20% worst or 20% best) over 5 years, were enrolled. Two years later, they were classified as periodontally declining (active periodontitis [AP]), if they had at least five teeth with probing depth (PD) ≥5 mm, or stable (stable periodontally [SP]), if they did not. Groups were compared with respect to demographics, PD, clinical loss of attachment, subgingival bacteria, serum hsCRP, interleukin (IL)-1β and -6, and chronic diseases.

    Results: Ten AP and 24 SP subjects were identified; 13% of women and 44% of men from the original sample were in the AP group (P <0.05). Most Asians were SP; most whites and all African Americans were classified as having AP (P <0.01). More AP elders had osteoporosis (P <0.01), but the AP and SP groups did not differ with respect to IL-1β and -6 or hsCRP. Bacterial counts were higher in the AP group for Parvimonas micra (previously Peptostreptococcus micros or Micromonas micros) (7.7 × 105 cells versus 3.8 × 105 cells; P <0.05), Prevotella intermedia (25.7 × 105 cells versus 9.8 × 105 cells; P <0.01), Tannerella forsythia (previously T. forsythensis) (16.2 × 105 cells versus 8.0 × 105 cells; P <0.05), and Streptococcus mutans (6.2 × 105 cells versus 2.0 × 105 cells; P <0.01). Three risk factors were most predictive of periodontal decline: PD, osteoporosis, and being white or African American.

    Conclusion: Periodontal decline was associated with osteoporosis, ethnicity, PD, gender, serum hsCRP, and levels of four bacterial species.