Building a flagellum outside the bacterial cell

• Autores: Lewis D. B. Evans, Colin Hughes, Claire M. Fraser
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 10, 2014, págs. 566-572
• Idioma: inglés
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• Resumen

  • Flagella, the helical propellers that extend from the bacterial surface, are a paradigm for how complex molecular machines can be built outside the living cell. Their assembly requires ordered export of thousands of structural subunits across the cell membrane and this is achieved by a type III export machinery located at the flagellum base, after which subunits transit through a narrow channel at the core of the flagellum to reach the assembly site at the tip of the nascent structure, up to 20 μm from the cell surface. Here we review recent findings that provide new insights into flagellar export and assembly, and a new and unanticipated mechanism for constant rate flagellum growth.