Evidence of Periopathogenic Microorganisms in Placentas of Women With Preeclampsia

• Autores: Eli E. Machtei, Hannah Sprecher, Shlomi Barak, Orit Oettinger-Barak, Gonen Ohel
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 78, Nº. 4, 2007, págs. 670-676
• Idioma: inglés
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• Resumen

  • Evidence of Periopathogenic Microorganisms in Placentas of Women With Preeclampsia Shlomi Barak,* Orit Oettinger-Barak,† Eli E. Machtei,†‡ Hannah Sprecher,§ and Gonen Ohel*‡ *Department of Obstetrics and Gynecology, Bnai-Zion Medical Center, Haifa, Israel.

    †Periodontal Unit, Department of Oral and Dental Medicine, Rambam Health Care Center, Haifa, Israel.

    ‡Technion - Israel Institute of Technology - Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel.

    §Microbiology Laboratory, Rambam Health Care Center.

    Correspondence: Dr. Orit Oettinger-Barak, Periodontal Unit, Department of Oral and Dental Medicine, Rambam Health Care Center 31096, P.O. Box 9602, Haifa, Israel. Fax: 972-4-8543057; e-mail: o_o-barak@rambam.health.gov.il.

    Background: Periodontal disease is a chronic inflammatory infectious disease that may act as a focus of infection. Preeclampsia is a pregnancy-specific hypertensive disorder that often leads to maternal morbidity and mortality. Acute atherosis, the placental lesion of preeclampsia, shares many histopathological features with atherosclerosis. Recently, chronic infection was linked to the initiation of atherosclerosis. Oral pathogens have been detected in atherosclerotic plaques, where they may play a role in the development and progression of atherosclerosis. The purpose of the present study was to explore the possibility that periopathogenic bacteria may translocate into the placental tissues of women with preeclampsia.

    Methods: Samples were taken from 16 placentas obtained from cesarean sections of women with preeclampsia and from 14 age-matched healthy pregnant women. Polymerase chain reaction was used to detect Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum ssp., Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, and Treponema denticola.

    Results: Eight of the 16 (50%) placenta specimens were positive for one or more periopathogenic bacteria in the preeclampsia group, compared to only two of the 14 samples (14.3%) from controls. Bacterial counts were statistically significantly higher in the preeclampsia group for all of the periopathogenic bacteria examined (P ≤0.0055). Although all of the target periopathogenic bacteria were found in the preeclampsia group, only three (P. gingivalis, T. forsythensis, and T. denticola) were found in the control group.

    Conclusion: The significant presence of periopathogenic microorganisms or their products in human placentas of women with preeclampsia may suggest a possible contribution of periopathogenic bacteria to the pathogenesis of this syndrome.