Enhanced Bone Regeneration in Beagle Dogs With Bovine Bone Mineral Coated With a Synthetic Oligopeptide

• Autores: Soo-Boo Han, Jun-Beom Park, Jue-Yeon Lee, Yoon-Jeong Park, Sang-Hoon Rhee, Sang-Cheol Lee, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, Young Ku, In-Chul Rhyu, Chong-Pyoung Chung
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 78, Nº. 11, 2007, págs. 2150-2155
• Idioma: inglés
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• Resumen

  • Enhanced Bone Regeneration in Beagle Dogs With Bovine Bone Mineral Coated With a Synthetic Oligopeptide Jun-Beom Park,* Jue-Yeon Lee,† Yoon-Jeong Park,‡§ Sang-Hoon Rhee,§‖ Sang-Cheol Lee,† Tae-Il Kim,* Yang-Jo Seol,* Yong-Moo Lee,* Young Ku,*§ In-Chul Rhyu,* Soo-Boo Han,* and Chong-Pyoung Chung*§ *Department of Periodontology, School of Dentistry, Seoul National University, Seoul, Korea.

    †Nano-Intelligent Bioengineering Corp., Seoul, Korea.

    ‡Department of Craniomaxillofacial Reconstructive Sciences, School of Dentistry, Seoul National University.

    §Intellectual Biointerface Engineering Center, Korea Science and Engineering Foundation, Seoul, Korea.

    ‖Department of Dental Biomaterials Science, School of Dentistry, Seoul National University.

    Correspondence: Dr. Chong-Pyoung Chung, Department of Periodontology, School of Dentistry and Intellectual Biointerface Engineering Center, Seoul National University, 28-2 Yongon-Dong, Chongno-Gu, Seoul 110-749, Korea. Fax: 82-2-744-0051; e-mail: jbassoonis@yahoo.co.kr.

    Background: Recombinant human bone morphogenic protein-2 stimulates bone augmentation in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance guided bone regeneration in the beagle 3-wall defect model and the clinical implications.

    Methods: The second and fourth mandibular premolars of four adult beagle dogs were extracted bilaterally, and the extraction sites were allowed to heal for 2 months. An L-shaped defect was prepared at the central part of the extraction site with a round bur on a low-speed motor. Peptide-coated bone mineral was implanted on one side, and uncoated bone mineral was implanted on the other side. The membrane was tucked underneath the mobilized lingual flap. New bone formation at the test and control sites was determined at 4 weeks.

    Results: No specimen revealed any evidence of infection or foreign body reaction, and all wounds showed a good healing response. Sites augmented with peptide-coated bone mineral and uncoated mineral exhibited excellent maintenance of the ridge contour. There was more new bone at sites with peptide-coated bone mineral than at control sites. The new bone in sites with peptide-coated bone mineral was deposited evenly around the graft material, and bone mineral was integrated fully into the new bone.

    Conclusion: Deproteinized cancellous bovine bone coated with synthetic oligopeptides enhanced new bone formation, and it seemed to be a better material for guided bone regeneration in the beagle L-shaped defect model.

    KEYWORDS: Animal studies, bone regeneration, oligopeptide Cited by Seung-Yun Shin, You-Jeong Hwang, Jung-Hoon Kim and Yang-Jo Seol. (2014) Long-term results of new deproteinized bovine bone material in a maxillary sinus graft procedure. Journal of Periodontal & Implant Science 44, 259.

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    CrossRef Jun-Beom Park, Kwangsu Lee, Won Lee, Heesung Kim, KyoungHwa Lee and InSoo Kim. (2013) Establishment of the chronic bone defect model in experimental model mandible and evaluation of the efficacy of the mesenchymal stem cells in enhancing bone regeneration. Tissue Engineering and Regenerative Medicine 10, 18-24.

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    Online publication date: 1-Apr-2010.

    CrossRef Jue-Yeon Lee, Jung-Eun Choo, Young-Suk Choi, Jin-Sook Suh, Seung-Jin Lee, Chong-Pyoung Chung and Yoon-Jeong Park. (2009) Osteoblastic differentiation of human bone marrow stromal cells in self-assembled BMP-2 receptor-binding peptide-amphiphiles. Biomaterials 30, 3532-3541.

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    CrossRef Richard T. Kao, Shinya Murakami and O. Ross Beirne. (2009) The use of biologic mediators and tissue engineering in dentistry. Periodontology 2000 50:10.1111/prd.2009.50.issue-1, 127-153.

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