Effect of a Hydroxyapatite Tricalcium Phosphate Alloplast on Osseous Repair in the Rat Calvarium

• Autores: Kurt B. Fleckenstein, Michael F. Cuenin, Mark E. Peacock, Michael A. Billman, Gary D. Swiec, Thomas B. Buxton, Baldev B. Singh, James C. McPherson
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 77, Nº. 1, 2006, págs. 39-45
• Idioma: inglés
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  • Correspondence: Dr. Mark E. Peacock, 500 Scotts Way, Augusta, GA 30909. E-mail: mark.peacock@lnd.amedd.army.mil.

    Background: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA-TCP) on osseous repair in the rat calvarium.

    Methods: Forty-four adult male Harlan Sprague-Dawley rats were assigned to one of four treatment groups: HA-TCP macroporous disk, HA-TCP microporous disk, HA-TCP granules, and demineralized freeze-dried bone (DFDB). The materials were placed into 8-mm calvarial critical-size defects (CSD). Calvariae were harvested at 10 weeks post-surgery and evaluated histomorphometrically.

    Results: The DFDB group had significantly (P <0.05) more new bone formation (47%) than any other group. The HA-TCP macroporous disk group had significantly (P <0.05) more new bone formation (19.7%) than the HA-TCP microporous disk (8.5%) or HA-TCP granule (6.9%) groups.

    Conclusions: The HA-TCP macroporous disk may elicit significant new bone formation due to its rigid space-maintaining scaffold and pore size for vascular ingrowth. It is well tolerated by host tissues and may be a suitable carrier for growth factors.