Resumen de Effects of a Mineralized Human Cancellous Bone Allograft in Regeneration of Mandibular Class II Furcation Defects

Tae-Ju Oh, Hom-Lay Wang, Yi-Pin Tsao, Rodrigo F. Neiva, Khalaf Al-Shammari

• Effects of a Mineralized Human Cancellous Bone Allograft in Regeneration of Mandibular Class II Furcation Defects Yi-Pin Tsao,* Rodrigo Neiva,* Khalaf Al-Shammari,† Tae-Ju Oh,* and Hom-Lay Wang* *Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI.

  †Specialized Center for the Advancement of Dental Services, Ministry of Health, Kuwait.

  Correspondence: Dr. Hom-Lay Wang, Department of Periodontics/Prevention/Geriatrics, University of Michigan School of Dentistry, 1011 N. University Ave., Ann Arbor, MI 48109-1078. Fax: 734/936-0374; e-mail: homlay@umich.edu.

  Background: A solvent-preserved, mineralized human cancellous bone allograft (MBA) was recently developed. However, its effect in regenerating furcation defects remains to be determined. Hence, the aim of the study is to evaluate the effects of this newly introduced MBA, with and without a bioabsorbable collagen membrane, for the treatment of mandibular class II furcation defects.

  Methods: Thirty subjects with Hamp's Class II buccal or lingual furcation defects in lower molars were randomly assigned to open flap debridement (OFD), MBA, or MBA with a bioabsorbable collagen membrane (guided tissue regeneration [GTR] + MBA) groups. Clinical and defect measurements were obtained at the initial visit and at 6-month reentry surgeries. The data were analyzed for intra- and intergroup comparisons and associations of treatment with probability of clinical improvement.

  Results: Out of a total of 30 subjects, 27 individuals completed the study. Vertical bone fill (VBF) was −1.6 ± 2.1 mm in OFD, 1.9 ± 1.4 mm in MBA, and 0.7 ± 0.9 mm in GTR + MBA groups. VBF in MBA and GTR + MBA groups was significantly higher than that in the OFD group (P <0.05). Horizontal bone fill (HBF) was 0.2 ± 1.7 mm, 1.1 ± 0.9 mm, and 1.1 ± 0.9 mm for OFD, MBA, and GTR + MBA groups, respectively. However, HBF, recession, clinical attachment level gain, and probing depth reduction at furcations showed no differences among groups.

  Conclusions: Results obtained from this study indicate that solvent-preserved, mineralized human cancellous allograft, with or without collagen membrane, can significantly improve bone fill in mandibular Class II furcation defects. In addition, initial vertical defect depth was found to be the only factor that was associated with a higher probability of clinical improvement.

  KEYWORDS: Allograft, debridement, furcation defect, guided tissue regeneration, membranes, regeneration Cited by Kyung-Nam Moon, Su-Gwan Kim, Ji-Su Oh, Chun-Sung Kim, Sung-Chul Lim and Mi-Ae Jeong. (2015) Evaluation of Bone Formation After Grafting With Deproteinized Bovine Bone and Mineralized Allogenic Bone. Implant Dentistry 24, 101-105.

  Online publication date: 1-Feb-2015.

  CrossRef Filippo Graziani, Stefano Gennai, Dimitra Karapetsa, Stefano Rosini, Natalia Filice, Mario Gabriele and Maurizio Tonetti. (2015) Clinical performance of access flap in the treatment of class II furcation defects. A systematic review and meta-analysis of randomized clinical trials. Journal of Clinical Periodontology 42:10.1111/jcpe.2015.42.issue-2, 169-181.

  Online publication date: 1-Feb-2015.

  CrossRef Gustavo Avila-Ortiz, Juan G. De Buitrago and Michael S. Reddy. (2015) Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop. Journal of Periodontology 86:2-s, S108-S130.

  Online publication date: 1-Feb-2015.

  Abstract | Full Text | PDF (888 KB) | PDF Plus (881 KB) N. Tovar, R. Jimbo, R. Gangolli, L. Perez, L. Manne, D. Yoo, F. Lorenzoni, L. Witek and P.G. Coelho. (2014) Evaluation of bone response to various anorganic bovine bone xenografts: an experimental calvaria defect study. International Journal of Oral and Maxillofacial Surgery 43, 251-260.

  Online publication date: 1-Feb-2014.

  CrossRef Nick Tovar, Ryo Jimbo, Riddhi Gangolli, Lukasz Witek, Fabio Lorenzoni, Charles Marin, Lakshmipradha Manne, Lucia Perez-Troisi, Marta Baldassarri and Paulo G. Coelho. (2013) Modification of Xenogeneic Graft Materials for Improved Release of P-15 Peptides in a Calvarium Defect Model. The Journal of Craniofacial Surgery, 1.

  Online publication date: 1-Nov-2013.

  CrossRef Pavan Bajaj, A. R. Pradeep, Esha Agarwal, Nishanth S. Rao, Savitha B. Naik, N. Priyanka and Nitish Kalra. (2013) Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. Journal of Periodontal Research 48:10.1111/jre.2013.48.issue-5, 573-581.

  Online publication date: 1-Oct-2013.

  CrossRef Tsung-Hung Chen, Yu-Kang Tu, Chia-Chen Yen and Hsein-Kun Lu. (2013) A systematic review and meta-analysis of guided tissue regeneration/osseous grafting for the treatment of Class II furcation defects. Journal of Dental Sciences 8, 209-224.

  Online publication date: 1-Sep-2013.

  CrossRef Yung-Ting Hsu and Hom-Lay Wang. (2013) How to Select Replacement Grafts for Various Periodontal and Implant Indications. Clinical Advances in Periodontics 3:3, 167-179.

  Online publication date: 1-Aug-2013.

  Abstract | Full Text | PDF (2881 KB) | PDF Plus (1001 KB) Robert Bagoff, Sachin Mamidwar, Ioana Chesnoiu-Matei, John L. Ricci, Harold Alexander and Nick M. Tovar. (2013) Socket Preservation and Sinus Augmentation Using a Medical Grade Calcium Sulfate Hemihydrate and Mineralized Irradiated Cancellous Bone Allograft Composite. Journal of Oral Implantology 39, 363-371.

  Online publication date: 1-Jun-2013.

  CrossRef Markus Schlee and Daniel Rothamel. (2013) Ridge Augmentation Using Customized Allogenic Bone Blocks. Implant Dentistry, 1.

  Online publication date: 1-Apr-2013.

  CrossRef Asim Alsuwaiyan, Bing-Yan Wang and Robert E Cohen. (2012) Phenotypic characterization of mononuclear inflammatory cells following equine hydroxyapatite/collagen block grafting in rats. Biomedical Materials 7, 065005.

  Online publication date: 1-Dec-2012.

  CrossRef Michele Jacotti, Hom-Lay Wang, Jia-Hui Fu, Giuseppe Zamboni and Fabio Bernardello. (2012) Ridge Augmentation With Mineralized Block Allografts. Implant Dentistry, 1.

  Online publication date: 1-Oct-2012.

  CrossRef Emiko SAITO, Akira SAITO, Yoshinori KUBOKI, Mariko KIMURA, Yoshiyuki HONMA, Tomomi TAKAHASHI and Masamitsu KAWANAMI. (2012) Periodontal repair following implantation of beta-tricalcium phosphate with different pore structures in class III furcation defects in dogs. Dental Materials Journal 31, 681-688.

  Online publication date: 1-Jan-2012.

  CrossRef Anuj Sharma and A.R. Pradeep. (2011) Autologous Platelet-Rich Fibrin in the Treatment of Mandibular Degree II Furcation Defects: A Randomized Clinical Trial. Journal of Periodontology 82:10, 1396-1403.

  Online publication date: 1-Oct-2011.

  Abstract | Full Text | PDF (484 KB) | PDF Plus (535 KB) Bassam Michael Kinaia, Jacob Steiger, Anthony L. Neely, Maanas Shah and Monish Bhola. (2011) Treatment of Class II Molar Furcation Involvement: Meta-Analyses of Reentry Results. Journal of Periodontology 82:3, 413-428.

  Online publication date: 1-Mar-2011.

  Abstract | Full Text | PDF (1187 KB) | PDF Plus (786 KB) Carlo Maria Soardi, Sergio Spinato, Davide Zaffe and Hom-Lay Wang. (2010) Atrophic maxillary floor augmentation by mineralized human bone allograft in sinuses of different size: an histologic and histomorphometric analysis. Clinical Oral Implants Research, no-no.

  Online publication date: 1-Dec-2010.

  CrossRef Paul D. Fotek, Rodrigo F. Neiva and Hom-Lay Wang. (2009) Comparison of Dermal Matrix and Polytetrafluoroethylene Membrane for Socket Bone Augmentation: A Clinical and Histologic Study. Journal of Periodontology 80:5, 776-785.

  Online publication date: 1-May-2009.

  Abstract | Full Text | PDF (1908 KB) | PDF Plus (735 KB) Ana L. Eto, Julio C. Joly, Marjorie Jeffcoat, Ney S. de Araújo, Vera C. de Araújo and Patricia R. Cury. (2007) Use of Anorganic Bovine-Derived Hydroxyapatite Matrix/Cell-Binding Peptide (P-15) in the Treatment of Class II Furcation Defects: A Clinical and Radiographic Study in Humans. Journal of Periodontology 78:12, 2277-2283.

  Online publication date: 1-Dec-2007.

  Abstract | Full Text | PDF (560 KB) | PDF Plus (207 KB) Hom-Lay Wang and Yi-Pin Tsao. (2007) Mineralized Bone Allograft-Plug Socket Augmentation: Rationale and Technique. Implant Dentistry 16, 33-41.

  Online publication date: 1-Jan-2007.