Effect of a Controlled-Release Chlorhexidine Chip on Clinical and Microbiological Parameters and Prostaglandin E2 Levels in Gingival Crevicular Fluid

• Autores: Gülseren Samancı Aktar, Fikret İpek, Tansel Mızrak, Güliz N. Güncü, Feriha Çağlayan, Tansel Ansal Balcı
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 77, Nº. 3, 2006, págs. 437-443
• Idioma: inglés
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• Resumen

  • Effect of a Controlled-Release Chlorhexidine Chip on Clinical and Microbiological Parameters and Prostaglandin E2 Levels in Gingival Crevicular Fluid Tansel Mızrak,* Güliz N. Güncü,† Feriha Çaǧlayan,† Tansel Ansal Balcı,‡ Gülseren Samancı Aktar,§ and Fikret İpek* *Department of Periodontology, Faculty of Dentistry, Dicle University, Diyarbakır, Turkey.

    †Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, 06100 Sıhhiye, Turkey.

    ‡Department of Nuclear Medicine, Faculty of Medicine, Fırat University, Elazıǧ, Turkey.

    §Department of Microbiology, Faculty of Medicine, Dicle University.

    Correspondence: Dr. Güliz N. Güncü, Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Sıhhiye 06100, Turkey. Fax: 90-312-310-4440; e-mail: dt_gulizgungor@hotmail.com.

    Background: The aim of the present study was to determine the effect of a chlorhexidine chip on crevicular prostaglandin E2 (PGE2) levels and on the clinical and microbiological parameters of periodontitis when used as adjunctive therapy to scaling and root planing (SRP) in patients with chronic periodontitis.

    Methods: This randomized single-blind study was carried out in parallel design. The test group received SRP plus chlorhexidine chip, whereas the control group received SRP alone. Thirty-four subjects, aged 20 to 55 years, with chronic periodontitis were recruited. Clinical indices, microbiological samples, and gingival crevicular fluid (GCF) samples were evaluated at baseline and after 1, 3, and 6 months. Microbiological samples were evaluated under a light microscope. GCF PGE2 levels were determined using radioimmunoassay.

    Results: Significant improvements could be found for all clinical variables in both groups over the study period. The mean changes in probing depth obtained by SRP plus chlorhexidine chip were greater than those obtained by the SRP alone group at 3 and 6 months. In the test group, there was also significant gain in clinical attachment level at 6 months. When data were combined from all groups, significant reductions in GCF PGE2 levels and number of microorganisms were noted at all time points. However, in the test group, reduction was greater at 6 months for crevicular PGE2 level and at 3 and 6 months for proportions of spirochetes.

    Conclusion: Based on the findings of this study, the chlorhexidine chip reduced GCF PGE2 levels and had positive effects on clinical parameters and subgingival flora when used as adjunctive therapy to SRP in patients with chronic periodontitis.

    KEYWORDS: Chlorhexidine/therapeutic use, drug delivery systems, gingival crevicular fluid/analysis, prostaglandin E Cited by Paula Matesanz-Pérez, María García-Gargallo, Elena Figuero, Antonio Bascones-Martínez, Mariano Sanz and David Herrera. (2013) A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis. Journal of Clinical Periodontology 40:10.1111/jcpe.2013.40.issue-3, 227-241.

    Online publication date: 1-Mar-2013.

    CrossRef J Cosyn, SR Miremadi, MM Sabzevar and H De Bruyn. (2013) Clinical effects of an essential oil solution used as a coolant during ultrasonic root debridement. International Journal of Dental Hygiene 11:10.1111/idh.2013.11.issue-1, 62-68.

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    CrossRef Paula Matesanz, David Herrera, Ana Echeverría, Ana O’Connor, Itziar González and Mariano Sanz. (2013) A randomized clinical trial on the clinical and microbiological efficacy of a xanthan gel with chlorhexidine for subgingival use. Clinical Oral Investigations 17, 55-66.

    Online publication date: 1-Jan-2013.

    CrossRef Jose R. Gonzales, Lutz Harnack, Gabriella Schmitt-Corsitto, Rolf H. Boedeker, Trinad Chakraborty, Eugen Domann and Joerg Meyle. (2011) A Novel Approach to the Use of Subgingival Controlled-Release Chlorhexidine Delivery in Chronic Periodontitis: A Randomized Clinical Trial. Journal of Periodontology 82:8, 1131-1139.

    Online publication date: 1-Aug-2011.

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    CrossRef Thomas Attin, Thaer Abouassi, Klaus Becker, Annette Wiegand, Malgorzata Roos and Rengin Attin. (2008) A new method for chlorhexidine (CHX) determination: CHX release after application of differently concentrated CHX-containing preparations on artificial fissures. Clinical Oral Investigations 12, 189-196.

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    CrossRef Michele Paolantonio, Matteo D'Angelo, Roberto Felice Grassi, Giuseppe Perinetti, Raffaele Piccolomini, Giuseppe Pizzo, Marco Annunziata, Domenico D'Archivio, Simonetta D'Ercole, Gianna Nardi and Luigi Guida. (2008) Clinical and Microbiologic Effects of Subgingival Controlled-Release Delivery of Chlorhexidine Chip in the Treatment of Periodontitis: A Multicenter Study. Journal of Periodontology 79:2, 271-282.

    Online publication date: 1-Feb-2008.

    Abstract | Full Text | PDF (976 KB) | PDF Plus (357 KB) Lucila Busch, Leonor Sterin-Borda and Enri Borda. (2008) β-Adrenoceptor alterations coupled with secretory response and experimental periodontitis in rat submandibular glands. Archives of Oral Biology 53:6, 509.