Resumen de Analysis of Tumor Necrosis Factor-α, Transforming Growth Factor-β, Interleukin-10, IL-6, and Interferon-γ Gene Polymorphisms in Patients With Chronic Periodontitis
Nina Babel, Georgy Cherepnev, Hans-Dieter Volk, Petra Reinke
Background: Cytokine gene polymorphisms may have an impact on the susceptibility to and progression of chronic periodontitis. In this study, we analyzed the −1082 interleukin-10 (IL-10), −308 tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta 1 (TGF-β1) (codons 10 and 25), −174IL-6, and +874 interferon-gamma (IFN-γ) gene single-nucleotide polymorphisms in a cohort of patients with chronic periodontal disease.
Methods: The diagnosis was made on the basis of standardized clinical and radiographic criteria. A total of 122 adult patients with chronic periodontitis and 114 unrelated, ethnically and age-matched white control subjects were genotyped by a polymerase chain reaction–sequence-specific primer.
Results: The number of individuals carrying the −174IL-6 CC genotype was significantly higher in the group of patients than in the control group (odds ratio [OR] = 1.896; 95% confidence interval [CI] = 1.106 to 3.250; P = 0.0283). The TGF-β1 (codon 25) GG (Arg25/Arg25) genotype was detected more frequently in control subjects than in periodontitis patients (OR = 0.459; 95% CI = 0.230 to 0.920; P = 0.0421).
Conclusion: The −174IL-6 and TGF-β1 (codon 25) single-nucleotide polymorphisms are associated with susceptibility to chronic periodontitis in the population studied.
