Resumen de The Influence of Cyclosporin A on Mechanical Retention of Dental Implants Previously Integrated to the Bone: A Study in Rabbits

Celso Eduardo Sakakura, Rogerio Margonar, Juliana A.N.D. Morais, Elcio Marcantonio Jr.

• Background: Immunosuppressive agents may induce severe changes on bone metabolism and may impair the osseointegration process during the implant healing. No data are available concerning the influence of cyclosporin A on dental implants previously integrated to the bone. The aim of this study was to evaluate the influence of cyclosporin A administration on the mechanical retention of bone previously integrated to dental implants.

  Methods: Eighteen female New Zealand rabbits were submitted to an implant surgery. Each animal received one commercial dental implant of 10 × 3.75 mm. After 12 weeks of an undisturbed healing period, six animals were randomly sacrificed and the removal torque test was performed (group A). In addition, six animals were submitted to a daily injection of cyclosporin A in a dosage of 10 mg/kg (group C), and six animals received saline solution as a control (group B). After 12 weeks of cyclosporin A administration, groups B and C were sacrificed and submitted to a removal torque test in which higher values can be interpreted as higher mechanical bone retention to the implant surface or higher osseointegration.

  Results: The removal torque results were 30.5 (±9.8) Ncm for group A, 50.17 (±17.5) Ncm for group B, and 26 (±7.8) Ncm for group C. The statistical analysis showed significant differences between groups A and B (P <0.05) and groups B and C (P <0.01).

  Conclusion: Cyclosporin A administration may impair the mechanical retention of dental implants previously integrated to the bone.