Alveolar Bone Regeneration for Immediate Implant Placement Using an Injectable Bone Substitute:: An Experimental Study in Dogs
- Autores: Damien Boix, Olivier Gauthier, Jérôme Guicheux, Paul Pilet, Pierre Weiss, Gaël Grimandi, Guy Daculsi
- Localización: Journal of periodontology, ISSN 0022-3492, Vol. 75, Nº. 5, 2004, págs. 663-671
- Idioma: inglés
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Resumen
Background: The aim of the present study was to assess the efficacy of a ready-to-use injectable bone substitute for bone regeneration around dental implants placed into fresh extraction sockets.
Methods: Third and fourth mandibular premolars were extracted from three beagle dogs and the interradicular septa were surgically reduced to induce a mesial bone defect. Thereafter, titanium implants were immediately placed. On the left side of the jaw, mesial bone defects were filled with an injectable bone substitute (IBS), obtained by combining a polymer and biphasic calcium phosphate ceramic granules. The right defects were left unfilled as controls. After 3 months of healing, specimens were prepared for histological and histomorphometric evaluations.
Results: No post-surgical complications were observed during the healing period. In all experimental conditions, histological observations revealed a lamellar bone formation in contact with the implant. Histomorphometric analysis showed that IBS triggers a significant (P <0.05) increase in terms of the number of threads in contact with bone, bone-to-implant contact, and peri-implant bone density of approximately 8.6%, 11.0%, and 14.7%, respectively. In addition, no significant difference was observed when number of threads, bone-to-implant contact, and bone density in the filled defects were compared to the no-defect sites.
Conclusion: It is concluded that an injectable bone substitute composed of a polymeric carrier and calcium phosphate significantly increases bone regeneration around immediately placed implants. J Periodontol 2004;75:663-671.
